{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:28:38Z","timestamp":1791894518814,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["JY\u2010079"],"award-info":[{"award-number":["JY\u2010079"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872756"],"award-info":[{"award-number":["31872756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunomodulation of tumor\u2010associated macrophages (TAMs) into tumor\u2010inhibiting M1\u2010like phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47, a \u201cdon't eat me\u201d signal that ligates with the signal regulatory protein alpha (SIRP\u03b1) on macrophages to escape phagocytosis. Thus, effective re\u2010education of TAMs into the \u201ceat me\u201d type and blocking the CD47\u2010SIRP\u03b1 signaling play pivotal roles in tumor immunotherapy. Herein, it is reported that hybrid nanovesicles (hEL\u2010RS17) derived from extracellular vesicles of M1 macrophages and decorated with RS17 peptide, an antitumor peptide that specifically binds to CD47 on tumor cells and blocks CD47\u2010SIRP<jats:italic>\u03b1<\/jats:italic> signaling, can actively target tumor cells and remodel TAM phenotypes. Consequently, more M1\u2010like TAMs infiltrate into tumor tissue to phagocytize more tumor cells due to CD47 blockade. By further co\u2010encapsulating chemotherapeutic agent shikonin, photosensitizer IR820, and immunomodulator polymetformin in hEL\u2010RS17, an enhanced antitumor effect is obtained due to the combinational treatment modality and close synergy among each component. Upon laser irradiation, the designed SPI@hEL\u2010RS17 nanoparticles exert potent antitumor efficacy against both 4T1 breast tumor and B16F10 melanoma models, which not only suppresses primary tumor growth but also inhibits lung metastasis and prevents tumor recurrence, exhibiting great potential in boosting CD47 blockade\u2010based antitumor immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.202303835","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T14:39:45Z","timestamp":1688049585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Extracellular Vesicles\u2010Derived Hybrid Nanoplatforms for Amplified CD47 Blockade\u2010Based Cancer Immunotherapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Lu","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hening","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"},{"name":"NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4793-1705","authenticated-orcid":false,"given":"Xing\u2010Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China  No. 11, First North Road Zhongguancun Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00972-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32160-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01267-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0236-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00737-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2990"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0183-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01328-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0462-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01206-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202204765"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005562"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3768"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106654"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.040"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.256"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04431-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02242"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121369"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20723-x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.09.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11822"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-016-0201-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121832"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110364"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30716"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120761"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.635485"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08619"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105376"},{"key":"e_1_2_9_37_1","first-page":"5417","volume":"15","author":"Shilnikova K.","year":"2018","journal-title":"Oncol. Lett."},{"key":"e_1_2_9_37_2","first-page":"8104","volume":"22","author":"Tang Z. Y.","year":"2018","journal-title":"Riv. Eur. Sci. Med. Farmacol."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109258"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23194-w"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14982"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2310"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108908"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202001704"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b07371"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206851"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109984"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202303835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:20:35Z","timestamp":1759782035000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202303835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":47,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/adma.202303835"],"URL":"https:\/\/doi.org\/10.1002\/adma.202303835","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"assertion":[{"value":"2023-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2303835"}}