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Nevertheless, their sensitivity needs to be improved for real\u2010world applications, especially for small\u2010molecule detection. This work demonstrates an optical microfiber biosensor for dopamine (DA) detection based on the DA\u2010binding\u2010induced aptamer conformational transitions that occur at plasmonic coupling sites on a double\u2010amplified nanointerface. The sensor exhibits ultrahigh sensitivity when detecting DA molecules at the single\u2010molecule level; additionally, this work provides an approach for overcoming optical device sensitivity limits, further extending optical fiber single\u2010molecule detection to a small molecule range (e.g., DA and metal ions). The selective energy enhancement and signal amplification at the binding sites effectively avoid nonspecific amplification of the whole fiber surface which may lead to false\u2010positive results. The sensor can detect single\u2010molecule DA signals in body\u2010fluids. It can detect the released extracellular DA levels and monitor the DA oxidation process. An appropriate aptamer replacement allows the sensor to be used for the detection of other target small molecules and ions at the single\u2010molecule level. This technology offers alternative opportunities for developing noninvasive early\u2010stage diagnostic point\u2010of\u2010care devices and flexible single\u2010molecule detection techniques in theoretical research.<\/jats:p>","DOI":"10.1002\/adma.202304116","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T18:12:11Z","timestamp":1687371131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Plasmonic Coupling on an Optical Microfiber Surface: Enabling Single\u2010Molecule and Noninvasive Dopamine Detection"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7528-1001","authenticated-orcid":false,"given":"Yunyun","family":"Huang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center The first Affiliated Hospital, &amp; Clinical Neuroscience Institute Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai\u2010Ou","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics Technology Jinan University  Guangzhou 511143 China"},{"name":"Department of Neurology and Stroke Center The first Affiliated Hospital, &amp; Clinical Neuroscience Institute Jinan University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1406"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3413"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00252"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.11.1474"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.11.021"},{"key":"e_1_2_9_2_4","first-page":"397","volume":"20","author":"Brunelin J.","year":"2013","journal-title":"Curr. 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