{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:30:25Z","timestamp":1791991825119,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21975133"],"award-info":[{"award-number":["21975133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370844"],"award-info":[{"award-number":["82370844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The eradication of osteomyelitis caused by methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) poses a significant challenge due to its development of biofilm\u2010induced antibiotic resistance and impaired innate immunity, which often leads to frequent surgical failure. Here, the design, synthesis, and performance of X\u2010ray\u2010activated polymer\u2010reinforced nanotherapeutics that modulate the immunological properties of infectious microenvironments to enhance chemoradiotherapy against multidrug\u2010resistant bacterial deep\u2010tissue infections are reported. Upon X\u2010ray radiation, the proposed polymer\u2010reinforced nanotherapeutic generates reactive oxygen species and reactive nitrogen species. To robustly eradicate MRSA biofilms at deep infection sites, these species can specifically bind to MRSA and penetrate biofilms for enhanced chemoradiotherapy treatment. X\u2010ray\u2010activated nanotherapeutics modulate the innate immunity of macrophages to prevent the recurrence of osteomyelitis. The remarkable anti\u2010infection effects of these nanotherapeutics are validated using a rat osteomyelitis model. This study demonstrates the significant potential of a synergistic chemoradiotherapy and immunotherapy method for treating MRSA biofilm\u2010infected osteomyelitis.\n                  <\/jats:p>","DOI":"10.1002\/adma.202304991","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T17:03:21Z","timestamp":1708967001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Enhanced Chemoradiotherapy for MRSA\u2010Infected Osteomyelitis Using Immunomodulatory Polymer\u2010Reinforced Nanotherapeutics"],"prefix":"10.1002","volume":"36","author":[{"given":"Yufei","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Surgery of Traditional Chinese Medicine Tianjin Hospital  Tianjin 300211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengpeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin 300060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin 300060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy  Tianjin 300060 China"},{"name":"Department of Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-1659","authenticated-orcid":false,"given":"Xinge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials College of Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00084-17"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-019-0061-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00686-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.02.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.936285"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0019-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00037"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00359"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08702"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008720"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201903018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02919-15"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00682-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31479-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202104024"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18268-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102926"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802244"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03682"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32054-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007488"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812272"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl504044p"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c02472"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201808024"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR07444K"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201905226"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000195"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.082"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101447"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27351"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121577"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127812"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c00001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201504536"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01010"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.13495"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-010-9047-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2008.08.001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05042"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130090"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001205"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700996"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201504536"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01010"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QM00481F"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11422"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b03067"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00922-3"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02702"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00052-18"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111066"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.03.022"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206959"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011617"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222981"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104223"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201100651"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101380"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201907954"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05493"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b05810"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605509"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08714"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002794"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126821"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2109"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00767-0"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02174-2"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00381.2001"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01486"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101505"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100962"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202304991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:14:28Z","timestamp":1759752868000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202304991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,3]]},"references-count":76,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/adma.202304991"],"URL":"https:\/\/doi.org\/10.1002\/adma.202304991","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,3]]},"assertion":[{"value":"2023-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2304991"}}