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Here, a method is reported to improve enzyme activity by adjusting the spatial position of a single\u2010atom site on the nanoplatforms. Two types of Cu single\u2010atom site nanozymes are synthesized in the interlayer (Cu\n                    <jats:sub>L<\/jats:sub>\n                    \/PHI) and in\u2010plane (Cu\n                    <jats:sub>P<\/jats:sub>\n                    \/PHI) of poly (heptazine imide) (PHI) through different synthesis pathways. Experimental and theoretical analysis indicates that the interlayer position of PHI can effectively adjust the coordination number, coordination bond length, and electronic structure of Cu single atoms compared to the in\u2010plane position, thereby promoting photoinduced electron migration and O\n                    <jats:sub>2<\/jats:sub>\n                    activation, enabling effective generate reactive oxygen species (ROS). Under visible light irradiation, the photocatalytic bactericidal activity of Cu\n                    <jats:sub>L<\/jats:sub>\n                    \/PHI against aureus is \u2248100%, achieving the same antibacterial effect as antibiotics, after 10\u00a0min of low\u2010dose light exposure and 2\u00a0h of incubation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202305077","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T04:40:30Z","timestamp":1690432830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Spatial Position Regulation of Cu Single Atom Site Realizes Efficient Nanozyme Photocatalytic Bactericidal Activity"],"prefix":"10.1002","volume":"35","author":[{"given":"Honghui","family":"Ou","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Xi'an Jiaotong University  Xi'an 710049 P. R. 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