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In this work, a novel diketopyrrolopyrrole\u2010based photothermal reagent (DCN) with unique J\u2010aggregation\u2010induced redshift is synthesized to achieve efficient tumor thermal ablation under safe power (0.33\u00a0W\u00a0cm<jats:sup>\u22122<\/jats:sup>). Meanwhile, <jats:italic>S<\/jats:italic>\u2010nitroso\u2010<jats:italic>N<\/jats:italic>\u2010acetylpenicillamine (SNAP) is co\u2010loaded with near\u2010infrared\u2010absorbing DCN in amphiphilic polymers to realize heat\u2010induced massive release of nitric oxide (NO), which can form oxidant peroxynitrite (ONOO<jats:sup>\u2212<\/jats:sup>) to active matrix metalloproteinases (MMPs), thereby degrading the compact tumor extracellular matrix to improve the ablation depth and infiltration of immune cells. Through a facile supramolecular assembly method, the DCN\/SNAP nanoparticles are anchored to liquid\u2010nitrogen\u2010frozen cancer cells, achieving enhanced antitumor immune responses and effective inhibition of distant tumors and pulmonary metastases after only one treatment. The safety and effectiveness of this supramolecular cell\u2010conjugation platform are verified by 2D\/3D cellular experiments and bilateral tumor model, confirming the thermal\u2010ablation\u2013gas\u2010permeation\u2013antigen\u2010presentation therapeutic mode has promising anticancer prospects.<\/jats:p>","DOI":"10.1002\/adma.202305287","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T04:41:00Z","timestamp":1691383260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["\u201cIce and Fire\u201d Supramolecular Cell\u2010Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Antitumor Immunity"],"prefix":"10.1002","volume":"35","author":[{"given":"Meng","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Macau 999078 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