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Monkeypox lesions are typically ulcers or pustules (containing high titers of replication\u2010competent virus) in the skin and mucous membranes, which allow monkeypox virus to transmit predominantly through intimate contact. Currently, effective clinical treatments for monkeypox are lacking, and strategies for blocking virus transmission are fraught with drawbacks. Herein, this work constructs a biomimetic nanotemplate (termed TBD@M NPs) with macrophage membranes as the coat and polymeric nanoparticles loading a versatile aggregation\u2010induced emission featured photothermal molecule TPE\u2010BT\u2010DPTQ as the core. In a surrogate mouse model of monkeypox (vaccinia\u2010virus\u2010infected tail scarification model), intravenously injected TBD@M NPs show precise tracking and near\u2010infrared region II fluorescence imaging of the lesions. Upon 808\u00a0nm laser irradiation, the virus is eliminated by the photothermal effect and the infected wound heals rapidly. More importantly, the inoculation of treated lesion tissue suspensions does not trigger tail infection or inflammatory activation in healthy mice, indicating successful blockage of virus transmission. This study demonstrates for the first time monkeypox theranostics using nanomedicine, and may bring a new insight into the development of a viable strategy for monkeypox management in clinical trials.<\/jats:p>","DOI":"10.1002\/adma.202305378","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T14:19:11Z","timestamp":1699280351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Aggregation\u2010Induced Emission\u2010Based Macrophage\u2010Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox"],"prefix":"10.1002","volume":"36","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Burn Surgery Department of Clinical Laboratory Institute of Translational Medicine The First People's Hospital of Foshan  Foshan Guangdong 528000 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