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The injury of annulus fibrosus (AF) caused by acupuncture or discectomy can trigger IVDD again. However, there is currently no suitable method for treating AF injury. In this study, the high\u2010strength smart microneedles (MNs) which can penetrate the AF tissue through a local and minimally invasive method, and achieve remote control of speeded\u2010up release of the drug and hyperthermia by the Near Infrared is developed. The PDA\/GelMA composite MNs loaded with diclofenac sodium are designed to extracellularly \u201coffend\u201d the inflammatory microenvironment and mitigate damage to cells, and intracellularly increase the level of cytoprotective heat shock proteins to enhance the defense against the hostile microenvironment, achieving \u201coffensive and defensive\u201d effects. In vitro experiments demonstrate that the synergistic treatment of photothermal therapy and anti\u2010inflammation effectively reduces inflammation, inhibits cell apoptosis, and promotes the synthesis of the extracellular matrix (ECM). In vivo experiments show that the MNs mitigate the inflammatory response, promote ECM deposition, reduce the level of apoptosis, and restore the biomechanical properties of the intervertebral disc (IVD) in rats. Overall, this high\u2010strength smart MNs display promising \u201coffensive and defensive\u201d effects that can provide a new strategy for IVD repair.<\/jats:p>","DOI":"10.1002\/adma.202305468","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:30:51Z","timestamp":1694158251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["High\u2010Strength Smart Microneedles with \u201cOffensive and Defensive\u201d Effects for Intervertebral Disc Repair"],"prefix":"10.1002","volume":"36","author":[{"given":"Qingchen","family":"Meng","sequence":"first","affiliation":[{"name":"Medical 3D Printing Center Orthopedic Institute Department of Orthopedic Surgery The First Affiliated Hospital School of Biology and Basic Medical Sciences Suzhou Medical College Soochow University  Suzhou Jiangsu 215000 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