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Here, a new magnetic\u2010resonance\u2010imaging (MRI)\u2010based imaging modality is presented that allows for efficient and longitudinal monitoring of NAFLD and NASH progression. The imaging modality uses manganese\u2010ion (Mn<jats:sup>2+<\/jats:sup>)\u2010chelated bilirubin nanoparticles (Mn@BRNPs) as a reactive\u2010oxygen\u2010species (ROS)\u2010responsive MRI imaging probe. Longitudinal <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted MR imaging of NASH model mice is performed after injecting Mn@BRNPs intravenously. The MR signal enhancement in the liver relative to muscle gradually increases up to 8 weeks of NASH progression, but decreases significantly as NASH progresses to the cirrhosis\u2010like stage at weeks 10 and 12. A new dual input pseudo\u2010three\u2010compartment model is developed to provide information on NASH stage with a single MRI scan. It is also demonstrated that the ROS\u2010responsive Mn@BRNPs can be used to monitor the efficacy of potential anti\u2010NASH drugs with conventional MRI. The findings suggest that the ROS\u2010responsive Mn@BRNPs have the potential to serve as an efficient MRI contrast for monitoring NASH progression and its transition to the cirrhosis\u2010like stage.<\/jats:p>","DOI":"10.1002\/adma.202305830","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T08:23:08Z","timestamp":1709972588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Longitudinal Magnetic Resonance Imaging with ROS\u2010Responsive Bilirubin Nanoparticles Enables Monitoring of Nonalcoholic Steatohepatitis Progression to Cirrhosis"],"prefix":"10.1002","volume":"36","author":[{"given":"Wonsik","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Center for Precision Bio\u2010Nanomedicine Korea Advanced Institute of Science and Technology (KAIST)  291 Daehak\u2010ro Daejeon 34141 South 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