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To address this issue, a multifunctional liposome, namely, Lip\u2010DTI\/NO, integrating a type\u2010I photosensitizer DTITBT with glutathione (GSH) or heat\u2010responsive nitric oxide (NO) donor S\u2010nitroso\u2010N\u2010acetyl\u2010D\u2010penicillamine (SNAP) is constructed to deplete the tumor ECM, leading to enhanced drug delivery and consequently improved phototherapy. The loaded DTITBT possesses multiple functions including NIR\u2010II fluorescence imaging, efficient superoxide radical (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ) generation and excellent photothermal conversion efficiency, making it feasible for precisely pinpointing the tumor in the phototherapy process. Responding to the intracellular overexpressed glutathione or heat produced by photothermal effect of DTITBT, NO can be released from SNAP. Upon 808\u00a0nm laser irradiation, Lip\u2010DTI\/NO could selectively induce in situ generation of peroxynitrite anion (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) in tumor after cascade processes including O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    production, GSH or heat\u2010triggered NO release, and rapid reaction between O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    and NO. The generated ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    could activate the expression of endogenous matrix metalloproteinases which could efficiently digest collagen of tumor ECM, thus facilitating enhanced penetration and accumulation of Lip\u2010DTI\/NO in tumor. In vivo evaluation demonstrates the notable therapeutic efficacy via ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010potentiated synergistic photodynamic\u2010photothermal therapies on both subcutaneous and orthotopic pancreatic cancer model.\n                  <\/jats:p>","DOI":"10.1002\/adma.202306476","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T14:03:05Z","timestamp":1703858585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Photo\u2010Triggered Cascade Therapy: A NIR\u2010II AIE Luminogen Collaborating with Nitric Oxide Facilitates Efficient Collagen Depletion for Boosting Pancreatic Cancer Phototheranostics"],"prefix":"10.1002","volume":"36","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Material Science and Engineering Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Dai","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Jin","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Material Science and Engineering Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0293-964X","authenticated-orcid":false,"given":"Ben Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen, (CUHK\u2010Shenzhen) Guangdong 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_7_2_1","first-page":"395","volume":"2020","author":"Mizrahi J. 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