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Hyperglycemia\u2010caused inflammation and excessive reactive oxygen species (ROS) are common obstacles encountered in DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate and inclusive methods are still lacking to target these two aspects and break the vicious cycle. This study proposes a novel approach for treating DFU wounds, utilizing an immunomodulatory hydrogel to achieve self\u2010cascade glucose depletion and ROS scavenging to regulate the diabetic microenvironment. Specifically, AuPt@melanin\u2010incorporated (GHM3) hydrogel dressing is developed to facilitate efficient hyperthermia\u2010enhanced local glucose depletion and ROS scavenging. Mechanistically, in vitro\/vivo experiments and RNA sequencing analysis demonstrate that GHM3 disrupts the ROS\u2010inflammation cascade cycle and downregulates the ratio of M1\/M2 macrophages, consequently improving the therapeutic outcomes for dorsal skin and DFU wounds in diabetic rats. In conclusion, this proposed approach offers a facile, safe, and highly efficient treatment modality for DFUs.<\/jats:p>","DOI":"10.1002\/adma.202306632","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T02:46:51Z","timestamp":1696646811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":395,"title":["An Immunomodulatory Hydrogel by Hyperthermia\u2010Assisted Self\u2010Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-7242","authenticated-orcid":false,"given":"Xiaoliang","family":"Qi","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erya","family":"Cai","sequence":"additional","affiliation":[{"name":"School &amp; Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Xiang","sequence":"additional","affiliation":[{"name":"School &amp; Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinXin","family":"Ge","sequence":"additional","affiliation":[{"name":"School &amp; Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Lan","sequence":"additional","affiliation":[{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang 325001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangbin","family":"Xu","sequence":"additional","affiliation":[{"name":"School &amp; 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