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Herein, this work creates a peptide\u2010drug conjugate (PDC) by linking 7\u2010ethyl\u201010\u2010hydroxycamptothecin (SN38) to hydrophilic segments with either RGDR or HKD motif at their C\u2010terminus through a glutathione\u2010responsive linker. The PDCs spontaneously assemble into filaments in aqueous solution. The PDC filaments containing 1% of SN38\u2010RGDR (SN38\u2010HKD\/RGDR) effectively target triple\u2010negative breast cancer (TNBC) cells and TECs with upregulated expression of integrin, and induce immunogenic cell death (ICD) of tumor cells and FasL downregulation of TECs. SN38\u2010HKD\/RGDR increases infiltration, activity, and viability of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and thus inhibits the growth of primary tumors and pulmonary metastasis. This study highlights the synergistic modulation of cancerous cells and TECs with integrin\u2010targeting PDC filaments as a promising strategy for TNBC chemoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202306676","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T15:33:43Z","timestamp":1697556823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inhibiting Endothelial Cell\u2010Mediated T Lymphocyte Apoptosis with Integrin\u2010Targeting Peptide\u2010Drug Conjugate Filaments for Chemoimmunotherapy of Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","volume":"36","author":[{"given":"Ying","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"},{"name":"University of Chinese Academy of 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