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Surface modification of these drugs with target ligands can promote their cellular internalization, but the modified drugs may be subjected to unexpected immune recognition and clearance. Herein, a phenylboronic acid (PBA) group\u2010shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)\u2010inducing agent (epirubicin, Epi) and an indoleamine 2,3\u2010dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for tumor chemo\u2010immunotherapy. This NLG919\u2010loaded Epi\u2010conjugated PEGylated dendrimers bridged with boronate bonds (NLG919@Epi\u2010DBP) maintains a stable nanostructure during circulation. Under a moderate acidic condition, the PBA group exposes to the sialic acid residue on the tumor cell membrane to enhance the internalization and penetration of NLG919@Epi\u2010DBP. At pH 5.0, NLG919@Epi\u2010DBP rapidly disassembles to release the incorporated Epi and NLG919. Epi triggers robust ICD of tumor cells that evokes strong immune response. In addition, inhibition of the IDO1 activity downregulates the metabolism of L\u2010tryptophan to kynurenine, leading to a reduction in the recruitment of immunosuppressive cells and modulation of the tumor immune microenvironment. 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