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To address this, this study introduces a novel hybrid fibroin fibrous scaffold (FFS) comprising randomly arranged fibroin fibers and vertically aligned cryogel fibers (CFs). The fibroin scaffold is efficiently degummed at room temperature and simultaneously formed a porous structure. The aligned CFs are produced via directional freeze\u2010drying, achieved by controlling solution concentration and freezing polymerization temperature. The incorporation of aligned CFs into the expanded fibroin fiber scaffold leads to enhanced cell infiltration both in vitro and in vivo, further elevating the hybrid scaffold's tissue compatibility. The anti\u2010inflammatory peptide 1 (AP\u20101) is also conjugated to the hybrid fibrous scaffold, effectively transforming the inflammatory status of chronic wounds from pro\u2010inflammatory to pro\u2010reparative. Consequently, the FFS\u2010AP1+CF group demonstrates superior granulation tissue formation, angiogenesis, collagen deposition, and re\u2010epithelialization during the proliferative phase compared to the commercial product PELNAC. Moreover, the FFS\u2010AP1+CF group displays epidermis thickness, number of regenerated hair follicles, and collagen density closer to normal skin tissue. These findings highlight the potential of random fibroin fibers\/aligned CFs hybrid fibrous scaffold as a promising approach for skin tissue filling and tissue regeneration.<\/jats:p>","DOI":"10.1002\/adma.202307328","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T06:40:22Z","timestamp":1706596822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Anti\u2010Inflammatory Peptide\u2010Conjugated Silk Fibroin\/Cryogel Hybrid Dual Fiber Scaffold with Hierarchical Structure Promotes Healing of Chronic Wounds"],"prefix":"10.1002","volume":"36","author":[{"given":"Ruyi","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery Affiliated Hospital of Nantong University  Nantong 226001 China"},{"name":"Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of the Chinese Academy of Sciences  Wenzhou 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