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The development of precise intraoperative imaging and postoperative residual removal techniques will facilitate the gross total elimination of GBM. Here, a self\u2010disassembling porphyrin lipoprotein\u2010coated calcium peroxide nanoparticles (PLCNP) is developed to target GBM via macropinocytosis, allowing for fluorescence\u2010guided surgery of GBM and improving photodynamic treatment (PDT) of GBM residual by alleviating hypoxia. By reducing self\u2010quenching and enhancing lysosome escape efficiency, the incorporation of calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    ) cores in PLCNP amplifies the fluorescence intensity of porphyrin\u2010lipid. Furthermore, the CaO\n                    <jats:sub>2<\/jats:sub>\n                    core has diminished tumor hypoxia and improves the PDT efficacy of PLCNP, enabling low\u2010dose PDT and reversing tumor progression induced by hypoxia aggravation following PDT. Taken together, this self\u2010disassembling and oxygen\u2010generating porphyrin\u2010lipoprotein nanoparticle may serve as a promising all\u2010in\u2010one nanotheranostic platform for guiding precise GBM excision and empowering post\u2010operative PDT, providing a clinically applicable strategy to combat GBM in a safe and effective manner.\n                  <\/jats:p>","DOI":"10.1002\/adma.202307454","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:30:33Z","timestamp":1706765433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Self\u2010Disassembling and Oxygen\u2010Generating Porphyrin\u2010Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic 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