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Optimizing ROS production is a primary objective for enhancing treatment efficiency. In this study, oxygen\u2010vacancy\u2010rich Pd\u2010integrated black barium titanate (BTO) nanoparticles are rationally engineered to boost the ROS generation efficiency via the introduction of Pd. Pd\u2010catalyzed hydrogenation at low temperatures narrows the bandgap of BTO and reduces the recombination rate of electron\u2010hole pairs. Furthermore, Pd has dual\u2010enzyme\u2010mimicking characteristics, including peroxidase\u2010 and catalase\u2010mimicking activities, which further heighten the therapeutic efficacy by enhancing ROS production and reversing the hypoxic tumor microenvironment. Importantly, the dual enzymatic activity of Pd can be amplified by multiple redox processes sparked by the piezoelectric potential under US stimulation, resulting in bilaterally enhanced multienzyme\u2010piezoelectric synergetic therapy. In vitro and in vivo results confirm high tumor inhibition in murine breast cancer cells. This work stresses the critical effects of defect engineering\u2010optimized piezodynamic tumor therapy.<\/jats:p>","DOI":"10.1002\/adma.202307568","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:53:47Z","timestamp":1696521227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Palladium\u2010Catalyzed Hydrogenation of Black Barium Titanate for Multienzyme\u2010Piezoelectric Synergetic Tumor Therapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Ruxi","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu  Chengdu Sichuan 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Shanghai Tenth People's Hospital Ultrasound Research and Education Institute Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment Tongji University Cancer Center School of Medicine Tongji University  Shanghai 200072 P. 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