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Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)\u2010triggered electrical stimulation (ES) and controllable drug release for repairing peripheral nerve injury are proposed. The inner layer of the NGCs is the barium titanate piezoelectric nanoparticles (BTNPs)\u2010doped polyvinylidene fluoride\u2010trifluoroethylene [BTNPs\/P(VDF\u2010TrFE)] electrospinning nanofibers with improved piezoelectricity and aligned orientation. The outer side of the NGCs is the thermoresponsive poly(N\u2010isopropylacrylamide) hybrid hydrogel with bioactive drug encapsulation. Such NGCs can not only induce neuronal\u2010oriented extension and promote neurite outgrowth with US\u2010triggered wireless ES, but also realize the controllable nerve growth factor release with the hydrogel shrinkage under US\u2010triggered heating. Thus, the NGC can positively accelerate the functional recovery and nerve axonal regeneration of rat models with long sciatic nerve defects. It is believed that the proposed US\u2010responsive aligned piezoelectric nanofibers derived hydrogel NGCs will find important applications in clinic neural tissue engineering.<\/jats:p>","DOI":"10.1002\/adma.202307896","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T20:26:45Z","timestamp":1715718405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":166,"title":["Ultrasound\u2010Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-4784","authenticated-orcid":false,"given":"Dongyu","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High\u2010Tech Key Laboratory for Bio\u2010Medical Research Southeast University  Nanjing 210096 China"},{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong 226001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Japan Friendship School of Clinical Medicine Peking University  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High\u2010Tech Key Laboratory for Bio\u2010Medical Research Southeast University  Nanjing 210096 China"},{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou 510060 P. 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