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Except for DC cells, targeting other immune cells, especially myeloid cells, is expected to address currently unmet clinical needs (e.g., tumor types, safety issues such as cytokine storms, and therapeutic benefits). Here, it is shown that an in situ injected macroporous myeloid cell adoptive scaffold (MAS) not only actively delivers antigens (Ags) that are triggered by scaffold\u2010infiltrating cell surface thiol groups but also releases granulocyte\u2013macrophage colony\u2010stimulating factor and other adjuvant combos. Consequently, this promotes cell differentiation, activation, and migration from the produced monocyte and DC vaccines (MASVax) to stimulate antitumor T\u2010cell immunity. Neoantigen\u2010based MASVax combined with immune checkpoint blockade induces rejection of established tumors and long\u2010term immune protection. The combined depletion of immunosuppressive myeloid cells further enhances the efficacy of MASVax, indicating the potential of myeloid cell\u2010based therapies for immune enhancement and normalization treatment of cancer.<\/jats:p>","DOI":"10.1002\/adma.202308155","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T19:18:15Z","timestamp":1706728695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Myeloid Cell\u2010Triggered In Situ Cell Engineering for Robust Vaccine\u2010Based Cancer Treatment"],"prefix":"10.1002","volume":"36","author":[{"given":"Wen\u2010Hao","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University  Beijing 100084 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