{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:06:55Z","timestamp":1788293215682,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51902136"],"award-info":[{"award-number":["51902136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180029"],"award-info":[{"award-number":["BK20180029"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The chemical, physical and biological effects of chiral nanomaterials have inspired general interest and demonstrated important advantages in fundamental science. Here, chiral iron oxide supraparticles (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs) modified by chiral penicillamine (Pen) molecules with\n                    <jats:italic>g<\/jats:italic>\n                    \u2010factor of \u22482 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    at 415\u00a0nm are fabricated, and these SPs act as high\u2010quality magnetic resonance imaging (MRI) contrast agents. Therein, the transverse relaxation efficiency and T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010MRI results demonstrated chiral Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs have a r\n                    <jats:sub>2<\/jats:sub>\n                    relaxivity of 157.39 \u00b1 2.34 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7S\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs and 136.21 \u00b1 1.26 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7S\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs due to enhanced electronic transition dipole moment for\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs compared with\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs. The in vivo MRI results show that\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs exhibit two\u2010fold lower contrast ratio than\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs, which enhances targeted enrichment in tumor tissue, such as prostate cancer, melanoma and brain glioma tumors. Notably, it is found that\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs have 7.7\u2010fold higher affinity for the tumor cell surface receptor cluster\u2010of\u2010differentiation 47 (CD47) than\n                    <jats:italic>L<\/jats:italic>\n                    \u2010Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs. These findings uncover that chiral Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    SPs act as a highly effective MRI contrast agent for targeting and imaging broad tumors, thus accelerating the practical application of chiral nanomaterials and deepening the understanding of chirality in biological and non\u2010biological environments.\n                  <\/jats:p>","DOI":"10.1002\/adma.202308198","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:35:42Z","timestamp":1695022542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Chiral Iron Oxide Supraparticles Enable Enantiomer\u2010Dependent Tumor\u2010Targeted Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"35","author":[{"given":"Chen","family":"Li","sequence":"first","affiliation":[{"name":"International Joint Research Laboratory for Biointerface and Biodetection State Key Lab of Food Science and Resources School of Food Science and Technology Jiangnan University  Wuxi Jiangsu 214122 P. 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