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Therefore, real\u2010time monitoring and the moderate elimination of ROS is extremely important. In this study, a ROS\u2010responsive circular dichroic (CD) at 553\u00a0nm and magnetic resonance imaging (MRI) dual\u2010signals chiral manganese oxide (MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) nanoparticles (NPs) are designed and synthesized. Both the CD and MRI signals show excellent linear ranges for intracellular hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) concentrations, with limits of detection (LOD) of 0.0027\u00a0nmol\/10\n                    <jats:sup>6<\/jats:sup>\n                    cells and 0.016\u00a0nmol\/10\n                    <jats:sup>6<\/jats:sup>\n                    cells, respectively. The lower LOD achieved with CD detection may be attributable to its higher anti\u2010interference capability from the intracellular matrix. Importantly, ROS\u2010induced cell aging is intervened by chiral MnO\n                    <jats:sub>2<\/jats:sub>\n                    NPs via redox reactions with excessive intracellular ROS. In vivo experiments confirm that chiral MnO\n                    <jats:sub>2<\/jats:sub>\n                    NPs effectively eliminate ROS in skin tissue, reduce oxidative stress levels, and alleviate skin aging. This approach provides a new strategy for the diagnosis and treatment of age\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.202308469","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T02:45:16Z","timestamp":1695869116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sensitive and Selective Dual\u2010Mode Responses to Reactive Oxygen Species by Chiral Manganese Dioxide Nanoparticles for Antiaging Skin"],"prefix":"10.1002","volume":"36","author":[{"given":"Aihua","family":"Qu","sequence":"first","affiliation":[{"name":"International Joint Research Laboratory for Biointerface and Biodetection Jiangnan University  Wuxi Jiangsu 214122 China"},{"name":"State Key Laboratory of Food Science and Technology Jiangnan University Jiangsu 214122 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