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Herein, an injectable, antibacterial, self\u2010expanding, and self\u2010propelling hydrogel bioadhesive with procoagulant activity and rapid gelation is reported. This hydrogel combines spontaneous gas foaming and rapid Schiff base crosslinking for lethal massive hemorrhage. Hydrogels have rapid gelation and expansion rate, high self\u2010expanding ratio, excellent antibacterial activity, antioxidant efficiency, and tissue adhesion capacity. In addition, hydrogels have good cytocompatibility, procoagulant ability, and higher blood cell\/platelet adhesion activity than commercial combat gauze and gelatin sponge. The optimized hydrogel (OD\u2010C\/QGQL\u2010A30) exhibits better hemostatic ability than combat gauze and gelatin sponge in rat liver and femoral artery bleeding models, rabbit volumetric liver loss massive bleeding models with\/without anticoagulant, and rabbit liver and kidney incision bleeding models with bleeding site not visible. Especially, OD\u2010C\/QGQL\u2010A30 rapidly stops the bleedings from pelvic area of rabbit, and swine subclavian artery vein transection. Furthermore, OD\u2010C\/QGQL\u2010A30 has biodegradability and biocompatibility, and accelerates Methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> (MRSA)\u2010infected skin wound healing. This injectable, antibacterial, self\u2010expanding, and self\u2010propelling hydrogel opens up a new avenue to develop hemostats for lethal massive bleeding, abdominal organ bleeding, and bleeding from coagulation lesions.<\/jats:p>","DOI":"10.1002\/adma.202308701","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T06:36:10Z","timestamp":1700116570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Injectable Self\u2010Expanding\/Self\u2010Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-423X","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong 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