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Zinc\u2010based batteries (ZBs) are regarded as ideal energy suppliers for these biocompatible electronics, but the corresponding biocompatibility validation is still in the initial stage. Meanwhile, complicated working conditions and some extreme electrolyte environments raise strict challenges, leaving less choices for safe ZBs. Toward higher operating stability and biocompatibility, this work proposes a hydrogel electrolyte featuring the moisture maintaining ability and a robust interface, which could further provide a milder environment for Zn\u2010MnO<jats:sub>2<\/jats:sub> batteries and Zn\u2010air batteries. The cytotoxicity and tissue injury of batteries are evaluated with human cell lines and battery implantations on the animal models, which demonstrate the high biocompatibility\u00a0of ZBs, while preliminary wearable devices implementation further verifies their operating stability. This work may provide a pathway for developing and validating biocompatible ZBs, contributing to their future practical employment in relevant fields.<\/jats:p>","DOI":"10.1002\/adma.202308836","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T11:04:38Z","timestamp":1704366278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Validating Operating Stability and Biocompatibility Toward Safer\u00a0Zinc\u2010Based Batteries"],"prefix":"10.1002","volume":"36","author":[{"given":"Zhexuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 China"},{"name":"School of Materials Science and Engineering Hunan Provincial Key Laboratory of Electronic Packaging and Advanced Functional Materials Central South University  Changsha 410083 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