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Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and radiotherapy are currently available as treatment methods. However, drug resistance is a significant factor in the failure of lung cancer treatments. Novel therapeutics have been exploited to address complicated resistance mechanisms of lung cancer and the advancement of nanomedicine is extremely promising in terms of overcoming drug resistance. Nanomedicine equipped with multifunctional and tunable physiochemical properties in alignment with tumor genetic profiles can achieve precise, safe, and effective treatment while minimizing or eradicating drug resistance in cancer. Here, this work reviews the discovered resistance mechanisms for lung cancer chemotherapy, molecular targeted therapy, immunotherapy, and radiotherapy, and outlines novel strategies for the development of nanomedicine against drug resistance. This work focuses on engineering design, customized delivery, current challenges, and clinical translation of nanomedicine in the application of resistant lung cancer.<\/jats:p>","DOI":"10.1002\/adma.202308977","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:43:30Z","timestamp":1700095410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Nanomedicine Combats Drug Resistance in Lung Cancer"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-2395","authenticated-orcid":false,"given":"Xiuli","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology Department of Respiratory Huaxi MR Research Center (HMRRC) and Critical Care Medicine Institute of Respiratory Health Precision Medicine Center Frontiers Science Center for Disease\u2010Related Molecular Network State Key Laboratory of Biotherapy West China 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