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Here, high\u2010performance pluronic F127 (P127)\u2010modified gold shell (AuS)\u2010polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near\u2010infrared irradiation, the resultant P127\u2010AuS@CURs generate transient mild photothermia (TMP; \u224842\u00a0\u00b0C, 10 min), which facilitates their penetration through colonic mucus and favors multiple cellular processes, including cell internalization, lysosomal escape, and controlled CUR release. This strategy relieves intracellular oxidative stress, improves wound healing, and reduces immune responses by polarizing the proinflammatory M1\u2010type macrophages to the anti\u2010inflammatory M2\u2010type. Upon oral administration of hydrogel\u2010encapsulating P127\u2010AuS@CURs plus intestinal intralumen TMP, their therapeutic effects against acute and chronic UC are demonstrated to be superior to those of a widely used clinical drug, dexamethasone. The treatment of P127\u2010AuS@CURs (+ TMP) elevates the proportions of beneficial bacteria (e.g., <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Lachnospiraceae<\/jats:italic>), whose metabolites can also mitigate colitis symptoms by regulating genes associated with antioxidation, anti\u2010inflammation, and wound healing. Overall, the intestinal intralumen TMP offers a promising approach to enhance the therapeutic outcomes of noninvasive medicines against UC.<\/jats:p>","DOI":"10.1002\/adma.202309516","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T19:57:15Z","timestamp":1702411035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Transient Mild Photothermia Improves Therapeutic Performance of Oral Nanomedicines with Enhanced Accumulation in the Colitis Mucosa"],"prefix":"10.1002","volume":"36","author":[{"given":"Ya","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Resource Insects College of Sericulture Textile and Biomass Sciences Southwest University  Chongqing 400715 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangquan","family":"Gou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Resource Insects 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