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However, they often do not work well on tissues that are soaked in blood or other biological fluids, and organs that are typically exposed to a variety of harsh environments such as different pH values, nonhomogeneous distortions, continuous expansions and contractions, or high pressures. In this study, a nature\u2010derived multilayered hetero\u2010bioadhesive patch (skin secretion of\n                    <jats:italic>Andrias davidianus<\/jats:italic>\n                    (SSAD)\u2010Patch) based on hydrophilic\/hydrophobic pro\u2010healing bioadhesives derived from the SSAD is developed, which is designed to form pressure\u2010triggered strong adhesion with wet tissues. The SSAD\u2010Patch is successfully applied for the sealing and healing of tissue defects within 10 s in diverse extreme injury scenarios in vivo including rat stomach perforation, small intestine perforation, fetal membrane defect, porcine carotid artery incision, and lung lobe laceration. The findings reveal a promising new type of self\u2010adhesive regenerative SSAD\u2010Patch, which is potentially adaptable to broad applications (under different pH values and air or liquid pressures) in sutureless wound sealing and healing.\n                  <\/jats:p>","DOI":"10.1002\/adma.202309774","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:35:19Z","timestamp":1710556519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Nature\u2010Derived, Hetero\u2010Structured, Pro\u2010Healing Bioadhesive Patch for High\u2010Performance Sealing of Wet Tissues"],"prefix":"10.1002","volume":"36","author":[{"given":"Shilin","family":"Liu","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Oral Disease and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical University  Chongqing 401174 P. 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