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However, the commonly employed small molecular iodinated contrast agents (ICAs) in clinical CT imaging have limitations such as nonspecific distribution in body, rapid clearance through kidneys, etc., leading to a narrow imaging time window. In contrast, existing nano\u2010sized ICAs face challenges like structural uncertainty, poor reproducibility, low iodine content, and uniformity issues. In this study, a novel approach is presented utilizing the aggregation\u2010induced emission luminogen (AIEgen) to design and fabricate a kind of monocomponent nano\u2010sized ICA (namely, BioDHU\u2010CT NPs) that exhibits a unique aggregation effect upon activation. The small sized BioDHU\u2010CT nanoparticles exhibit excellent tumor targeting capabilities and can release ICA modified with AIEgen with a high release efficiency up to 88.45%, under the activation of reactive oxygen species highly expressed in tumor regions. The released ICA performs in situ aggregation capability in the tumor region, which can enhance the retention efficiency of CT contrast agents, extending the imaging time window and improving the imaging quality in tumor regions.<\/jats:p>","DOI":"10.1002\/adma.202309789","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:50:38Z","timestamp":1700182238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Self\u2010Assembled Nano\u2010CT Contrast Agent Leveraging Size Aggregation for Improved In Vivo Tumor CT Imaging"],"prefix":"10.1002","volume":"36","author":[{"given":"Chengcheng","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhou","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200080 P. 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