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However, the limited stimulation capability poses significant challenges in advancing bacterial immunotherapy. Here, an adenosine 5\u2032\u2010triphosphate (ATP)\u2010responsive manganese (Mn)\u2010based bacterial material (\n                    <jats:italic>E. coli<\/jats:italic>\n                    @PDMC\u2010PEG (polyethylene glycol)) is engineered successfully, which exhibits an exceptional ability to synergistically activate the cGAS\u2010STING pathway. In the tumor microenvironment, which is characterized by elevated ATP levels, this biohybrid material degrades, resulting in the release of divalent manganese ions (Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ) and subsequent bacteria exposure. This combination synergistically activates the cGAS\u2010STING pathway, as Mn\n                    <jats:sup>2+<\/jats:sup>\n                    enhances the sensitivity of cGAS to the extracellular DNA (eDNA) secreted by the bacteria. The results of the in vivo experiments demonstrate that the biohybrid materials\n                    <jats:italic>E. coli<\/jats:italic>\n                    @PDMC\u2010PEG and VNP20009@PDMC\u2010PEG effectively inhibit the growth of subcutaneous melanoma in mice and in situ liver cancer in rabbits. Valuable insights for the development of bacteria\u2010based tumor immunotherapy are provided here.\n                  <\/jats:p>","DOI":"10.1002\/adma.202310189","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T23:39:17Z","timestamp":1709077157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["ATP\u2010Responsive Manganese\u2010Based Bacterial Materials Synergistically Activate the cGAS\u2010STING Pathway for Tumor Immunotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Huang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University  Hangzhou 310003 China"},{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310003 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