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However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug\u2010free approach by encapsulating black phosphorus (BP) and calcium peroxide (CaO<jats:sub>2<\/jats:sub>) in liposomes with surface\u2010modified triphenylphosphonium (BCLT) to develop mitochondria targeting calcification for cancer therapy without damaging normal cells. BCLT preferentially accumulates inside tumor mitochondria and then is activated by near\u2010infrared (NIR) laser irradiation to produce abundant PO<jats:sub>4<\/jats:sub><jats:sup>3\u2212<\/jats:sup> and Ca<jats:sup>2+<\/jats:sup> to accelerate in situ mitochondrial mineralization, leading to mitochondrial dysfunction and cancer cell death. More importantly, both PO<jats:sub>4<\/jats:sub><jats:sup>3\u2212<\/jats:sup> and Ca<jats:sup>2+<\/jats:sup> are essential components of metabolism in the body, and random gradient diffusion or premature leakage does not cause damage to adjacent normal cells. 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