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In addition, there is evidence that fallopian tubes contribute to the spread of endometriotic tissue as they serve as channels for proinflammatory media entering the abdominal cavity via retrograde menstruation. Here, stimuli\u2010degradable hydrogel implants are presented for the functional, biocompatible, and reversible occlusion of fallopian tubes. The hydrogel implants, designed with customized swelling properties, mechanically occlude fallopian tubes in a high\u2010performance manner with burst pressures reaching 255\u2013558\u00a0mmHg, exceeding normal abdominal pressures (95\u00a0mmHg). Their damage\u2010free removal can be achieved within 30 min using near\u2010visible UV light or a glutathione solution, employing a method akin to standard fallopian tube perfusion diagnostics. Ultrasound\u2010guided implant placement is demonstrated using a clinical hysteroscope in a human\u2010scale uterus model and biocompatibility in a porcine in vivo model. Importantly, the prevention of live sperm as well as endometrial cell passage through blocked fallopian tubes is demonstrated. Overall, a multifunctional system is presented that constitutes a possible means of on\u2010demand, reversible contraception along with the first\u2010ever mechanical approach to abdominal endometriosis prevention and treatment.<\/jats:p>","DOI":"10.1002\/adma.202310301","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T03:25:08Z","timestamp":1706757908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli\u2010Responsive Hydrogels"],"prefix":"10.1002","volume":"36","author":[{"given":"Alexandre H.C.","family":"Anthis","sequence":"first","affiliation":[{"name":"Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) Department of Mechanical and Process Engineering (D\u2010MAVT) ETH Zurich  Sonneggstrasse 3 Zurich 8092 Switzerland"},{"name":"Particles Biology 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