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This study introduces a novel approach to combat obesity using orally ingested self\u2010powered electrostimulators. These electrostimulators consist of piezoelectric BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    (BTO) particles conjugated with capsaicin (Cap) and aim to activate the vagus nerve. Upon ingestion by diet\u2010induced obese (DIO) mice, the BTO@Cap particles specifically target and bind to Cap\u2010sensitive sensory nerve endings in the gastric mucosa. In response to stomach peristalsis, these particles generate electrical signals. The signals travel via the gut\u2013brain axis, ultimately influencing the hypothalamus. By enhancing satiety signals in the brain, this neuromodulatory intervention reduces food intake, promotes energy metabolism, and demonstrates minimal toxicity. Over a 3\u2010week period of daily treatments, DIO mice treated with BTO@Cap particles show a significant reduction in body weight compared to control mice, while maintaining their general locomotor activity. Furthermore, this BTO@Cap particle\u2010based treatment mitigates various metabolic alterations associated with obesity. Importantly, this noninvasive and easy\u2010to\u2010administer intervention holds potential for addressing other intracerebral neurological diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.202310351","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:57:05Z","timestamp":1712645825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Orally Ingested Self\u2010Powered Stimulators for Targeted Gut\u2013Brain Axis Electrostimulation to Treat Obesity and Metabolic Disorders"],"prefix":"10.1002","volume":"36","author":[{"given":"Cam\u2010Hoa","family":"Mac","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Tsing Hua University  Hsinchu 30013 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Meng","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National 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