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Here, a bioresponsive sliver peroxide (Ag\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010based nanovesicle, named Ag\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    @BP\u2010MT@MM, is developed as a broad\u2010spectrum MBL inhibitor for combating MBL\u2010producing bacterial pneumonia. Ag\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticle is first orderly modified with bovine serum albumin and polydopamine to co\u2010load meropenem (MER) and [5\u2010(\n                    <jats:italic>p<\/jats:italic>\n                    \u2010fluorophenyl)\u20102\u2010ureido]\u2010thiophene\u20103\u2010carboxamide (TPCA\u20101) and then encapsulated with macrophage membrane (MM) aimed to target inflammatory lung tissue specifically. The resultant Ag\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    @BP\u2010MT@MM effectively abrogates MBL activity by displacing the Zn\n                    <jats:sup>2+<\/jats:sup>\n                    cofactor in MBLs with Ag\n                    <jats:sup>+<\/jats:sup>\n                    and displays potent bactericidal and anti\u2010inflammatory properties, specific targeting abilities, and great bioresponsive characteristics. After intravenous injection, the nanoparticles accumulate prominently at infection sites through MM\u2010mediated targeting . Ag\n                    <jats:sup>+<\/jats:sup>\n                    released from Ag\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition at the infection sites effectively inhibits MBL activity and overcomes the resistance of MBL\u2010producing bacteria to MER, resulting in synergistic elimination of bacteria in conjunction with MER. In two murine infection models of NDM\u20101\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    \u2010induced severe pneumonia and NDM\u20101\n                    <jats:sup>+<\/jats:sup>\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    \u2010induced sepsis\u2010related bacterial pneumonia, the nanoparticles significantly reduce bacterial loading, pro\u2010inflammatory cytokine levels locally and systemically, and the recruitment and activation of neutrophils and macrophages. This innovative approach presents a promising new strategy for combating infections caused by MBL\u2010producing carbapenem\u2010resistant bacteria.\n                  <\/jats:p>","DOI":"10.1002\/adma.202310532","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:01:01Z","timestamp":1702544461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bio\u2010Responsive Sliver Peroxide\u2010Nanocarrier Serves as Broad\u2010Spectrum Metallo\u2010\u03b2\u2010lactamase Inhibitor for Combating Severe Pneumonia"],"prefix":"10.1002","volume":"36","author":[{"given":"Hanqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"},{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint 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Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of 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