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Here, an unconventional osteogenic platform is reported that functions by promoting capture of inactive osteogenic growth factor molecules to the site of cell growth for subsequent integrin\u2010mediated activation, using a recombinant fragment of latent transforming growth factor beta\u2010binding protein\u20101 (rLTBP1). It is shown that rLTBP1 binds to the growth\u2010factor\u2010 and integrin\u2010binding domains of fibronectin on poly(ethyl acrylate) surfaces, which immobilizes rLTBP1 and promotes the binding of latency associated peptide (LAP), within which inactive transforming growth factor beta 1 (TGF\u2010\u03b21) is bound. rLTBP1 facilitates the interaction of LAP with integrin \u03b21 and the subsequent mechanically driven release of TGF\u2010\u03b21 to stimulate canonical TGF\u2010\u03b21 signaling, activating osteogenic marker expression in vitro and complete regeneration of a critical\u2010sized bone defect in vivo.<\/jats:p>","DOI":"10.1002\/adma.202310789","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T19:39:05Z","timestamp":1705952345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin\u2010Mediated Mechanical Activation of Growth Factors"],"prefix":"10.1002","volume":"36","author":[{"given":"Udesh","family":"Dhawan","sequence":"first","affiliation":[{"name":"Centre for the Cellular Microenvironment Mazumdar\u2010Shaw Advanced Research Centre University of Glasgow  Glasgow G116EW UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Wolfson Building University of Strathclyde  Glasgow G4 0NW UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F. 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