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Current pharmaceutical therapies and surgical modalities have been largely limited to regulating hair regrowth efficiently without side effects and lacking treatment compliance. Here, this work proposes a materiobiomodulation therapy (MBMT), wherein polydopamine (PDA) nanoparticles with redox activity can be modulated to have a stoichiometric ROS (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) donating ability. These nanoparticles can intracellularly deliver ROS with high\u2010efficiency via the clathrin\u2010dependent endocytosis process. Utilizing homozygote transgenic HyPerion (a genetically\u2010encoded H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    biosensor) mice, this work also achieves in vivo dynamic monitoring of intracellular H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    elevation induced by ROS donators. Subcutaneous administration with ROS donators results in rapid onset of TAT and subsequent hair regrowth with a specific ROS \u201chormesis effect.\u201d Mechanistically, ROS activate \u03b2\u2010catenin\u2010dependent Wnt signaling, upregulating hair follicle stem cell expression. This work further develops a microneedles patch for transdermal ROS delivery, demonstrating long\u2010term, low\u2010dose ROS release. Unlike photobiomodulation therapy (PBMT), MBMT requires no external stimuli, providing a convenient and efficient approach for clinical hair loss treatment. This material\u2010HF communication implicates new avenues in HF\u2010related diseases, achieving targeted ROS delivery with minimal side effects.\n                  <\/jats:p>","DOI":"10.1002\/adma.202311459","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T17:29:36Z","timestamp":1707758976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Materiobiomodulated ROS Therapy for De Novo Hair Growth"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-746X","authenticated-orcid":false,"given":"Long","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"},{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering School of Pharmacy East China University of Science and Technology  Shanghai 200237 China"},{"name":"Optogenetics &amp; Synthetic Biology Interdisciplinary Research Center Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering School of Pharmacy East China University of Science and Technology  Shanghai 200237 China"},{"name":"Optogenetics &amp; Synthetic Biology Interdisciplinary Research Center Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-7757","authenticated-orcid":false,"given":"Xue","family":"Qu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"},{"name":"Optogenetics &amp; Synthetic Biology Interdisciplinary Research Center Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1723543"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.070"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242281"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00103-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00626"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2016.08.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2256"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1814-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.08.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00371"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.11.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003638"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.035"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.04.015"},{"key":"e_1_2_9_17_1","volume-title":"Reactive Oxygen Species: Methods and Protocols","author":"Calvo\u2010S\u00e1nchez M. 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