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However, contemporary research often overlooks the retention of organic residues within the repair layer, which hinders the growth of dense crystals and compromises the properties of the repaired enamel. During the maturation of natural enamel, the organic matrix undergoes enzymatic processing to facilitate further crystal growth, resulting in a highly mineralized tissue. Inspired by this process, a biomimetic self\u2010maturation mineralization system is developed, comprising ribonucleic acid\u2010stabilized amorphous calcium phosphate (RNA\u2010ACP) and ribonuclease (RNase). The RNA\u2010ACP induces initial mineralization in the form of epitaxial crystal growth, while the RNase present in saliva automatically triggers a biomimetic self\u2010maturation process. The mechanistic study further indicates that RNA degradation prompts conformational rearrangement of the RNA\u2010ACP, effectively excluding the organic matter introduced earlier. This exclusion process promotes lateral crystal growth, resulting in the generation of denser enamel\u2010like apatite crystals that are devoid of organic residues. This strategy of eliminating organic residues from enamel crystals enhances the mechanical and physiochemical properties of the repaired enamel. The present study introduces a conceptual biomimetic mineralization strategy for effective enamel repair in clinical practice and offers potential insights into the mechanisms of biomineral formation.<\/jats:p>","DOI":"10.1002\/adma.202311659","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T10:38:35Z","timestamp":1704364715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Biomimetic Self\u2010Maturation Mineralization System for Enamel Repair"],"prefix":"10.1002","volume":"36","author":[{"given":"Chen","family":"Lei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University  Xi'an 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010yan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; 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