{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:41:30Z","timestamp":1791474090507,"version":"4.3.4"},"reference-count":107,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019099","name":"Neubauer Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005385","name":"Council for Higher Education","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100005385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the substantial advancement in developing various hydrogel microparticle (HMP) synthesis methods, emulsification through porous medium to synthesize functional hybrid protein\u2013polymer HMPs has yet to be addressed. Here, the aided porous medium emulsification for hydrogel microparticle synthesis (APME\u2010HMS) system, an innovative approach drawing inspiration from porous medium emulsification is introduced. This method capitalizes on emulsifying immiscible phases within a 3D porous structure for optimal HMP production. Using the APME\u2010HMS system, synthesized responsive bovine serum albumin (BSA) and polyethylene glycol diacrylate (PEGDA) HMPs of various sizes are successfully synthesized. Preserving protein structural integrity and functionality enable the formation of cytochrome c (cyt c) \u2013 PEGDA HMPs for hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) detection at various concentrations. The flexibility of the APME\u2010HMS system is demonstrated by its ability to efficiently synthesize HMPs using low volumes (\u224850\u00a0\u00b5L) and concentrations (100\u00a0\u00b5<jats:sc>m<\/jats:sc>) of proteins within minutes while preserving proteins\u2019 structural and functional properties. Additionally, the capability of the APME\u2010HMS method to produce a diverse array of HMP types enriches the palette of HMP fabrication techniques, presenting it as a cost\u2010effective, biocompatible, and scalable alternative for various biomedical applications, such as controlled drug delivery, 3D printing bio\u2010inks, biosensing devices, with potential implications even in culinary applications.<\/jats:p>","DOI":"10.1002\/adma.202311841","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T01:56:48Z","timestamp":1722563808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aided Porous Medium Emulsification for Functional Hydrogel Microparticles Synthesis"],"prefix":"10.1002","volume":"36","author":[{"given":"Tina","family":"Khairallah","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Technion Israel Institute of Technology  Haifa 32000 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-4917","authenticated-orcid":false,"given":"Luai R.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Technion Israel Institute of Technology  Haifa 32000 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.03.002"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2019.113480"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2019.05.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2007.06.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.8b03805"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr7090620"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.06.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2018.12.014"},{"key":"e_1_2_8_9_1","first-page":"1444","volume":"23","author":"B\u0142aszczyk M. M.","year":"2020","journal-title":"Int. J."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advwatres.2017.05.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2015.02.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0148-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.03.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2008.01.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9070545"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116831"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2013.06.046"},{"key":"e_1_2_8_20_1","first-page":"6520","volume":"9","author":"Li M.","year":"2022","journal-title":"Front. Nutr."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200083n"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201900071"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/s120608426"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202200385"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm800225v"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201910573"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-021-00243-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200602574"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201801095"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd9994"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050986"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11071656"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28134988"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200030"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3638-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm100931r"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b02591"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102735"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200700433"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00757-4"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC01305H"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201102560"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49244-4"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306862"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c22377"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40571-020-00384-9"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122331"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/nanomanufacturing3010002"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2014.11.010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/0104-6632.20150322s00003323"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.12962\/j20882033.v30i2.4997"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jchemed.6b00507"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-009-0566-8"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.7b02160"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjp-2018-0126"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.129997"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1201\/b18436-3"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-39683-5"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.2c01089"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11242-021-01705-z"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c01558"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.088963"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60065-0"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27744-0"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba6112"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c01534"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13312-0"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-015-0118-6"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1AN15738H"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mee.2015.04.004"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02197-9"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2019.11.009"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2019.06.283"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijap.2019v11i4.32080"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.06.022"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/s110605968"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2012_053"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC05327G"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2008.09.005"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2022.131966"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2021.120319"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12100971"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-7388(99)00334-8"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00099-5"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4041"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.01.018"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC01568A"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpe.14326"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/01932691.2017.1421082"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781501502071-013"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40571-020-00384-9"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.petrol.2021.109075"},{"key":"e_1_2_8_93_1","first-page":"93","volume":"74","author":"Othman N.","year":"2015","journal-title":"J. Teknol."},{"key":"e_1_2_8_94_1","first-page":"691","volume":"62","author":"Ilia Anisa A. N.","year":"2010","journal-title":"World Acad. Sci. Eng. Technol."},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/en16062538"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earscirev.2020.103439"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1088\/0256-307X\/22\/1\/045"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheatmasstransfer.2020.119967"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11242-022-01852-x"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9797(02)00047-4"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.desal.2007.10.052"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03425"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.2516\/ogst\/2020066"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.petrol.2020.108108"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102344"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802005-0.00028-8"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390701289292"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202311841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:06:14Z","timestamp":1759773974000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202311841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":107,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/adma.202311841"],"URL":"https:\/\/doi.org\/10.1002\/adma.202311841","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2023-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2311841"}}