{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:21:37Z","timestamp":1792016497553,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2022A001060"],"award-info":[{"award-number":["2022A001060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Disorders in the regulatory arm of the adaptive immune system result in autoimmune\u2010mediated diseases. While systemic immunosuppression is the prevailing approach to manage them, it fails to achieve long\u2010lasting remission due to concomitant suppression of the regulatory arm and carries the risk of heightened susceptibility to infections and malignancies. Alopecia areata is a condition characterized by localized hair loss due to autoimmunity. The accessibility of the skin allows\u00a0local rather than systemic intervention to avoid broad immunosuppression. It is hypothesized that the expansion of endogenous regulatory T cells (T\n                    <jats:sub>regs<\/jats:sub>\n                    ) at the site of antigen encounter can restore the immune balance and generate a long\u2010lasting tolerogenic response. A hydrogel microneedle (MN) patch is therefore utilized for delivery of CCL22, a T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010chemoattractant, and IL\u20102, a T\n                    <jats:sub>reg<\/jats:sub>\n                    \u00a0survival factor to amplify them. In an immune\u2010mediated murine model of alopecia, local bolstering of T\n                    <jats:sub>reg<\/jats:sub>\n                    \u00a0numbers is shown, leading to sustained hair regrowth and attenuation of inflammatory pathways. In a humanized skin transplant mouse model, expansion of T\n                    <jats:sub>regs<\/jats:sub>\n                    within human skin is confirmed without engendering peripheral immunosuppression. The patch offers high\u2010loading capacity and shelf\u2010life stability for prospective clinical translation. By harmonizing immune responses locally, the aim is to reshape the landscape of autoimmune skin disease management.\n                  <\/jats:p>","DOI":"10.1002\/adma.202312088","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T02:04:07Z","timestamp":1713492247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Microneedle\u2010Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune\u2010Mediated Alopecia"],"prefix":"10.1002","volume":"36","author":[{"given":"Nour","family":"Younis","sequence":"first","affiliation":[{"name":"Brigham and Woman's Hospital, Department of Medicine, Renal Division Harvard Medical School Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Puigmal","sequence":"additional","affiliation":[{"name":"Brigham and Woman's Hospital, Department of Medicine, 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