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However, rapid re\u2010epithelialization to restore tissue integrity and function in an adverse environment is challenging. In this work, a long\u2010term anti\u2010inflammatory and antioxidant hydrogel with mechanical stimulation for rapid re\u2010epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, and \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> nanoparticles is reported. Glycine\u2010modified supramolecular thioctic acid is stable and possesses outstanding mechanical properties. The incorporating \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> providing the potential contrast function for magnetic resonance imaging observation, can propel hydrogel reconfiguration to enhance the mechanical properties of the hydrogel underwater due to water\u2010initiated release of Fe<jats:sup>3+<\/jats:sup>. In vitro experiments show that the hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, and alleviated inflammation. The effect of rapid re\u2010epithelialization is ultimately demonstrated in a long urethral injury model in vivo, and the mechanical stimulation of hydrogels achieves effective functional replacement and ultimately accurate remodeling of the epithelium. Notably, the proposed strategy provides an advanced alternative treatment for patients in need of large\u2010area epithelial reconstruction.<\/jats:p>","DOI":"10.1002\/adma.202312740","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T19:38:40Z","timestamp":1706211520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mechanical Stimulation of Anti\u2010Inflammatory and Antioxidant Hydrogels for Rapid Re\u2010Epithelialization"],"prefix":"10.1002","volume":"36","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[{"name":"National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510006 P. R. 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