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Directly integrating durable protective coatings onto Mg surfaces is challenging because of intrinsic low coating compactness. Herein, inspired by tooth enamel, a novel highly compact dual\u2010protection inorganic\u2010protein (inorganic<jats:italic>Pro<\/jats:italic>) coating is in situ constructed on Mg surfaces through bovine serum albumin (BSA) protein\u2010boosted reaction between sodium fluoride (NaF) and Mg substrates. The association of Mg ions and BSA establishes a local hydrophobic domain that lowers the formation enthalpy of NaMgF<jats:sub>3<\/jats:sub> nanoparticles. This process generates finer nanoparticles that function as \u201cbricks,\u201d facilitating denser packing, consequently reducing voidage inside coatings by over 50% and reinforcing mechanical durability. Moreover, the incorporation of BSA in and on the coatings plays two synergistic roles: 1) acting as \u201cmortar\u201d to seal residual cracks within coatings, thereby promoting coating compactness and tripling anticorrosion performance, and 2) mitigating fouling\u2010accelerated biocorrosion in complex biosystems via tenfold resistance against biofoulant attachments, including biofluids, proteins, and metabolites. This innovative strategy, leveraging proteins to alter inorganic reactions, benefits the future coating design for Mg\u2010based and other metallic materials with tailored anticorrosion and antifouling performances.<\/jats:p>","DOI":"10.1002\/adma.202313211","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T05:14:11Z","timestamp":1707542051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dual\u2010Protection Inorganic\u2010Protein Coating on Mg\u2010Based Biomaterials through Tooth\u2010Enamel\u2010Inspired Biomineralization"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-2803","authenticated-orcid":false,"given":"Ziqian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemical and Materials Engineering University of Alberta  Edmonton Alberta T6G 1H9 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