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Single\u2010cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD. Considering the involvement of reactive oxygen species (ROS) as the primary instigator of pyroptosis and the lack of an efficient intervention approach, this study developed carbonized Mn\u2010containing nanodots (MCDs) as ROS\u2010scavenging catalytic biomaterials to suppress pyroptosis of nucleus pulposus (NP) cells to efficiently alleviate IVDD. Catalytic MCDs have superior efficacy in scavenging intracellular ROS and rescuing homeostasis in the NP microenvironment compared with N\u2010acetylcysteine, a classical antioxidant. The data validates that pyroptosis plays a vital role in mediating the protective effects of catalytic MCDs against oxidative stress. Systematic in vivo assessments substantiate the effectiveness of MCDs in rescuing a puncture\u2010induced IVDD rat model, further demonstrating their ability to suppress pyroptosis. This study highlights the potential of antioxidant catalytic nanomedicine as a pyroptosis inhibitor and mechanistically unveils an efficient strategy for the treatment of IVDD.<\/jats:p>","DOI":"10.1002\/adma.202313248","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:54:25Z","timestamp":1706777665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Catalytic Nanodots\u2010Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration"],"prefix":"10.1002","volume":"36","author":[{"given":"Kaiqiang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Changzheng Hospital Navy Medical University  Shanghai 200003 P. R. China"},{"name":"Department of Orthopedics Naval Medical Center of PLA  Shanghai 200052 P. R. 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