{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:49:53Z","timestamp":1785790193707,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC CoG SUPRAVACC 819856"],"award-info":[{"award-number":["ERC CoG SUPRAVACC 819856"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1551 (project No. 464588647)"],"award-info":[{"award-number":["SFB 1551 (project No. 464588647)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2516 (projectNo.405552959)"],"award-info":[{"award-number":["GRK 2516 (projectNo.405552959)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","award":["Kekule Fellowship"],"award-info":[{"award-number":["Kekule Fellowship"]}],"id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Printing of biologically functional constructs is significant for applications in tissue engineering and regenerative medicine. Designing bioinks remains remarkably challenging due to the multifaceted requirements in terms of the physical, chemical, and biochemical properties of the three\u2010dimensional matrix, such as cytocompatibility, printability, and shape fidelity. In order to promote matrix and materials stiffness, while not sacrificing stress relaxation mechanisms which support cell spreading, migration, and differentiation, this work reports an interpenetrating network (IPN) bioink design. The approach makes use of a chemically defined network, combining physical and chemical crosslinking units with a tunable composition and network density, as well as spatiotemporal control over post\u2010assembly material stiffening. To this end, star\u2010shaped poly(ethylene glycol)s functionalized with Phe\u2010Gly\u2010Gly tripeptide or photoactive stilbazolium are synthesized, and used to prepare three\u2010dimensional networks with cucurbit[8]uril (CB[8]) through supramolecular host\u2013guest complexation. The hydrogel obtained shows fast relaxation and thus supports the proliferation and differentiation of cells. Upon irradiation, the mechanical properties of the hydrogel can be rapidly adapted via selective photochemical dimerization of stilbazolium within CB[8], leading to IPNs with increased form stability while retaining the dynamic nature of the hydrogels. This modular approach opens new design opportunities for extrudable and cell\u2010friendly dynamic biomaterials for applications in 3D\u2010bioprinting.<\/jats:p>","DOI":"10.1002\/adma.202313270","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T23:19:30Z","timestamp":1711581570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cucurbit[8]uril Mediated Supramolecular and Photocrosslinked Interpenetrating Network Hydrogel Matrices for 3D\u2010Bioprinting"],"prefix":"10.1002","volume":"36","author":[{"given":"Yuqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry Johannes Gutenberg University Mainz  Duesbergweg 10\u201314 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Matthias","family":"Bimmermann","sequence":"additional","affiliation":[{"name":"Department of Chemistry Johannes Gutenberg University Mainz  Duesbergweg 10\u201314 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meik","family":"Neufurth","sequence":"additional","affiliation":[{"name":"Institute for Physiological Chemistry University Medical Center Mainz  Duesbergweg 6 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-4459","authenticated-orcid":false,"given":"Pol","family":"Besenius","sequence":"additional","affiliation":[{"name":"Department of Chemistry Johannes Gutenberg University Mainz  Duesbergweg 10\u201314 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1638-y"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104730"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901798"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2016.12.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020924"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB01005G"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201701089"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03182"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/7\/3\/035006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701026"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.09.033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.11.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100122"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00481"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.044"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4489"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00045"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008111"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000295"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c00861"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5b02859"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201411383"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01483-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201501234"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.06.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0954411915606935"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201501099"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c01906"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM01286E"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000179"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00341"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460675"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00680"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja106362w"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00273C"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2011.03.029"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol047866k"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11164g"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp50336d"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/b704817c"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/poc.2928"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja064323s"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC04748D"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b00959"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00478a039"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054298a"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2612-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.006"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20152"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-08-0493"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9408-6"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp060274b"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rby008"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202313270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:13:21Z","timestamp":1759756401000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202313270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":53,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/adma.202313270"],"URL":"https:\/\/doi.org\/10.1002\/adma.202313270","archive":["Portico"],"relation":{"is-basis-for":[{"id-type":"doi","id":"10.52843\/cassyni.ytr7c3","asserted-by":"object"},{"id-type":"doi","id":"10.52843\/cassyni.ytr7c3.4","asserted-by":"object"}]},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2313270"}}