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Here renal decellularized ECM (dECM) hydrogels are fabricated from porcine and human renal cortex as biomaterials to enrich cell\u2010to\u2010ECM crosstalk during the onset of kidney organoid differentiation from human pluripotent stem cells (hPSCs). Renal dECM\u2010derived hydrogels are used in combination with hPSC\u2010derived renal progenitor cells to define new approaches for 2D\u00a0and 3D\u00a0kidney organoid differentiation, demonstrating that in the presence of these biomaterials the resulting kidney organoids exhibit renal differentiation features and the formation of an endogenous vascular component. Based on these observations, a new method to produce kidney organoids with vascular\u2010like structures is achieved through the assembly of hPSC\u2010derived endothelial\u2010like organoids with kidney organoids in 3D. Major readouts of kidney differentiation and renal cell morphology are assessed exploiting these culture platforms as new models of nephrogenesis. 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