{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:32:11Z","timestamp":1792524731787,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207088"],"award-info":[{"award-number":["22207088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23B010004"],"award-info":[{"award-number":["LY23B010004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Given the challenge of multidrug resistance in antibiotics, non\u2010antibiotic\u2013dependent antibacterial strategies show promise for anti\u2010infective therapy. V\n                    <jats:sub>2<\/jats:sub>\n                    C MXene\u2010based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V\n                    <jats:sub>2<\/jats:sub>\n                    C MXene's laser irradiation to the near\u2010infrared region I (NIR\u2010I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single\u2010effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V\n                    <jats:sub>2<\/jats:sub>\n                    C, forming artificial nanoplatforms (Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C). Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C exhibits enhanced PCE (59.6%) and a longer irradiation laser (NIR\u2010II) due to the surface plasmon resonance effect of Pt NPs and V\n                    <jats:sub>2<\/jats:sub>\n                    C. Notably, Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C displays dual enzyme\u2010like activity with chemodynamic therapy (CDT) and NIR\u2010II enhanced dual enzyme\u2010like activity. The biocatalytic mechanism of Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C is elucidated using density functional theory. In an in vivo animal model, Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C effectively eliminates methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    from deep\u2010seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT\/CDT. Transcriptomic analysis reveals that Pt@V\n                    <jats:sub>2<\/jats:sub>\n                    C targets inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia\u2010amplified biocatalysis with Pt NPs and MXene nanocomposites.\n                  <\/jats:p>","DOI":"10.1002\/adma.202400366","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T07:34:53Z","timestamp":1710228893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Platinum Nanoparticles Regulated V\n                    <sub>2<\/sub>\n                    C MXene Nanoplatforms with NIR\u2010II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti\u2010Infective Therapy"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4313-6924","authenticated-orcid":false,"given":"Xiaojun","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Lv","sequence":"additional","affiliation":[{"name":"Joint Centre of Translational Medicine Department of Orthopaedics The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanghai Jiao Tong University  Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"Joint Centre of Translational Medicine Department of Orthopaedics The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325035 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