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Here, a phase\u2010junction nanomaterial (amorphous\u2010crystalline Cu<jats:sub>x<\/jats:sub>S\u2013Ag<jats:sub>2<\/jats:sub>S) is designed and prepared through a simple room temperature ion\u2010exchange process. A small amount of Ag<jats:sup>+<\/jats:sup> is added into Cu<jats:sub>7<\/jats:sub>S<jats:sub>4<\/jats:sub> nanocrystals, which transforms Cu<jats:sub>7<\/jats:sub>S<jats:sub>4<\/jats:sub> into amorphous phased Cu<jats:sub>x<\/jats:sub>S and produces crystalline Ag<jats:sub>2<\/jats:sub>S simultaneously. In this structure, the overhanging bonds on the amorphous Cu<jats:sub>x<\/jats:sub>S surface provide abundant active sites for optimizing the therapeutic activity. Meanwhile, the amorphous state enhances the photothermal effect through non\u2010radiative relaxation, and due to its low thermal resistance, phase\u2010junction Cu<jats:sub>x<\/jats:sub>S\u2013Ag<jats:sub>2<\/jats:sub>S forms a significant temperature gradient to unlock the optimized thermo\u2010electrodynamic therapy. Furthermore, benefiting from the high asymmetry of the amorphous state, the material forms a spin\u2010polarized state that can effectively inhibit electron\u2013hole recombination. In this way, the thermoelectric effect can facilitate the enzyme\u2010catalyzed cycle by providing electrons and holes, enabling an enhanced coupling of thermoelectric therapy with multienzyme activity, which induces excellent anti\u2010tumor performance. More importantly, the catalytic process simulated by density\u2010functional theory proves that Ag<jats:sup>+<\/jats:sup> alleviates the burden on the Cu sites through favorable adsorption of O<jats:sub>2<\/jats:sub> and prevents active site competition.<\/jats:p>","DOI":"10.1002\/adma.202400416","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T15:33:45Z","timestamp":1709134425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Phase Engineered Cu<sub>x<\/sub>S\u2013Ag<sub>2<\/sub>S with Photothermoelectric Activity for Enhanced Multienzyme Activity and Dynamic Therapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Pengyu","family":"Zang","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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