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Aggressive cytoreductive surgery (CRS) is the primary treatment for peritoneal metastasis. Unfortunately, this intensive treatment frequently causes clinical complications, such as postoperative recurrence, metastasis, and adhesion formation. Emerging evidence suggests that neutrophil extracellular traps (NETs) released by inflammatory neutrophils contribute to these complications. Effective NET\u2010targeting strategies thus show considerable potential in counteracting these complications but remain challenging. Here, one type of sulfoxide\u2010containing homopolymer, PMeSEA, with potent fouling\u2010resistant and NET\u2010inhibiting capabilities, is synthesized and screened. Hydrating sulfoxide groups endow PMeSEA with superior nonfouling ability, significantly inhibiting protein\/cell adhesion. Besides, the polysulfoxides can be selectively oxidized by ClO\n                    <jats:sup>\u2212<\/jats:sup>\n                    which is required to stabilize the NETs rather than H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , and ClO\n                    <jats:sup>\u2212<\/jats:sup>\n                    scavenging effectively inhibits NETs formation without disturbing redox homeostasis in tumor cells and quiescent neutrophils. As a result, PMeSEA potently prevents postoperative adhesions, significantly suppresses peritoneal metastasis, and shows synergetic antitumor activity with chemotherapeutic 5\u2010Fluorouracil. Moreover, coupling CRS with PMeSEA potently inhibits CRS\u2010induced tumor metastatic relapse and postoperative adhesions. Notably, PMeSEA exhibits low in vivo acute and subacute toxicities, implying significant potential for clinical postoperative adjuvant treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202400894","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T18:03:51Z","timestamp":1713463431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neutrophil Extracellular Traps\u2010Inhibiting and Fouling\u2010Resistant Polysulfoxides Potently Prevent Postoperative Adhesion, Tumor Recurrence, and Metastasis"],"prefix":"10.1002","volume":"36","author":[{"given":"Jiafeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Department of Gastroenterology of the Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310058 China"},{"name":"Department of Cell Biology and Department of Gastroenterology of the Fourth 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