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The modulation of the redox balance to scavenge reactive oxygen species emerges as a viable approach to addressing this concern. Selenoproteins, characterized by selenocysteine (SeCys\n                    <jats:sub>2<\/jats:sub>\n                    ) as the active center, are crucial for selenium\u2010based antioxidative stress therapy for inflammatory diseases. This study reveals that surface\u2010active elemental selenium (Se) nanoparticles, particularly lentinan\u2010Se (LNT\u2010Se), exhibit enhanced cellular accumulation and accelerated metabolism to SeCys\n                    <jats:sub>2<\/jats:sub>\n                    , the primary active Se form in biological systems. Consequently, LNT\u2010Se demonstrates significant inhibition of osteoclastogenesis. Furthermore, in vivo studies underscore the superior therapeutic efficacy of LNT\u2010Se over SeCys\n                    <jats:sub>2<\/jats:sub>\n                    , potentially attributable to the enhanced stability and safety profile of LNT\u2010Se. Specifically, LNT\u2010Se effectively modulates the expression of the selenoprotein GPx1, thereby exerting regulatory control over osteoclastogenesis inhibition, and the prevention of osteolysis. In summary, these results suggest that the prompt activation of selenoproteins by Se nanoparticles serves to suppress osteoclastogenesis and pathological bone loss by upregulating GPx1. Moreover, the utilization of bioactive Se species presents a promising avenue for effectively managing bone disorders.\n                  <\/jats:p>","DOI":"10.1002\/adma.202401620","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T19:10:25Z","timestamp":1713208225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Rapid Selenoprotein Activation by Selenium Nanoparticles to Suppresses Osteoclastogenesis and Pathological Bone Loss"],"prefix":"10.1002","volume":"36","author":[{"given":"Binhua","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital Department of Chemistry Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zushuang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital Department of Chemistry Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital Department of Chemistry Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital Department of Chemistry Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Food Safety and Nutrition Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6953-1342","authenticated-orcid":false,"given":"Tianfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery The First Affiliated Hospital Department of Chemistry Jinan University  Guangzhou 510632 China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Laboratory of Viral Pathogenesis &amp; Infection Prevention and Control of Ministry of Education Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University  Guangzhou 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay4447"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22565-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01527-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12122094"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2015.07.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00766-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.002"},{"key":"e_1_2_9_6_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28385-7"},{"key":"e_1_2_9_6_5","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01490-x"},{"key":"e_1_2_9_6_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211370"},{"key":"e_1_2_9_6_7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05174-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02490-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1556"},{"key":"e_1_2_9_7_3","first-page":"299","volume":"5","author":"Lee K. 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