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However, the clinical application of CTCs\u2010based diagnosis is largely limited by the challenges of capturing low\u2010abundance CTCs within a complex blood environment while ensuring them alive. Here, an ultrastrong ligand,\n                    <jats:sc>l<\/jats:sc>\n                    \u2010histidine\u2013\n                    <jats:sc>l<\/jats:sc>\n                    \u2010histidine (HH), specifically targeting sialylated glycans on the surface of CTCs, is designed. Furthermore, HH is integrated into a cell\u2010imprinted polymer, constructing a hydrogel with precise CTCs imprinting, high elasticity, satisfactory blood compatibility, and robust anti\u2010interference capacities. These features endow the hydrogel with excellent capture efficiency (&gt;95%) for CTCs in peripheral blood, as well as the ability to release CTCs controllably and alive. Clinical tests substantiate the accurate differentiation between liver cancer, cirrhosis, and healthy groups using this method. The remarkable diagnostic accuracy (94%), lossless release of CTCs, material reversibility, and cost\u2010effectiveness ($6.68 per sample) make the HH\u2010based hydrogel a potentially revolutionary technology for liver cancer diagnosis and single\u2010cell analysis.\n                  <\/jats:p>","DOI":"10.1002\/adma.202402379","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T07:13:51Z","timestamp":1713942831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual\u2010Histidine\u2010Based Cell Imprinted Hydrogels"],"prefix":"10.1002","volume":"36","author":[{"given":"Wenjing","family":"Sun","sequence":"first","affiliation":[{"name":"School of Life Sciences and Health Engineering Jiangnan University  Wuxi 214122 P. R. 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