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Here, is developed an ionic\u2010liquid\u2010based embolic material (LEAD) for portal vein embolization, liver ablation, and drug delivery. LEAD is optimized and characterized for diffusivity, X\u2010ray visibility, and cytotoxicity. In the porcine renal embolization model, LEAD delivered from the main renal artery reached vasculature down to 10 microns with uniform tissue ablation and delivery of small and large therapeutics. In non\u2010survival and survival porcine experiments, successful PVE is achieved in minutes, leading to the expected chemical segmentectomy, and delivery of a large protein drug (i.e., Nivolumab) with LEAD. In cholangiocarcinoma mouse tumor models and in ex vivo human tumors, LEAD consistently achieved an effective ablation and wide drug distribution. Furthermore, various strains of drug\u2010resistant patient\u2010derived bacteria showed significant susceptibility to LEAD, suggesting that LEAD may also prevent infectious complications resulting from tissue ablation. With its capabilities to embolize, ablate, and deliver therapeutics, ease of use, and a high safety profile demonstrated in animal studies, LEAD offers a potential alternative to tumor ablation with or without PVE for FLR growth.<\/jats:p>","DOI":"10.1002\/adma.202402570","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T02:33:27Z","timestamp":1714271607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Catheter\u2010Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablation"],"prefix":"10.1002","volume":"36","author":[{"given":"Enes","family":"Cevik","sequence":"first","affiliation":[{"name":"Division of Vascular &amp; Interventional Radiology Laboratory for Patient Inspired Engineering Mayo Clinic  13400 East Shea Blvd Scottsdale AZ 85259 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