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The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies are proving inadequate against the swift evolution of microbial resistance. Therefore, there is an urgent need to develop novel antimicrobial strategies with mechanisms distinct from those of existing antibiotics. Nanozybiotics, which are nanozyme\u2010based antimicrobials, mimic the catalytic action of lysosomal enzymes in innate immune cells to kill infectious pathogens. This review reinforces the concept of nanozymes and provides a comprehensive summary of recent research advancements on potential antimicrobial candidates. Initially, nanozybiotics are categorized based on their activities, mimicking either oxidoreductase\u2010like or hydrolase\u2010like functions, thereby highlighting their superior mechanisms in combating antimicrobial resistance. The review then discusses the progress of nanozybiotics in treating bacterial, viral, and fungal infections, confirming their potential as novel antimicrobial candidates. The translational potential of nanozybiotic\u2010based products, including hydrogels, nanorobots, sprays, bandages, masks, and protective clothing, is also considered. Finally, the current challenges and future prospects of nanozybiotic\u2010related products are explored, emphasizing the design and antimicrobial capabilities of nanozybiotics for future applications.<\/jats:p>","DOI":"10.1002\/adma.202403362","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:03:45Z","timestamp":1718363025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms"],"prefix":"10.1002","volume":"36","author":[{"given":"Caiyu","family":"Zhou","sequence":"first","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Chaoyang Beijing 100101 China"},{"name":"School of Life Sciences University of Chinese Academy of Sciences  Haidian Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Chaoyang Beijing 100101 China"},{"name":"School of Life Sciences University of Chinese Academy of Sciences  Haidian Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Cao","sequence":"additional","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Chaoyang Beijing 100101 China"},{"name":"School of Life Sciences University of Chinese Academy of Sciences  Haidian Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Chaoyang Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-4027","authenticated-orcid":false,"given":"Lizeng","family":"Gao","sequence":"additional","affiliation":[{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Chaoyang Beijing 100101 China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science Zhengzhou Henan 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"e_1_2_11_1_1","unstructured":"WHO The top 10 causes of death https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/the\u2010top\u201010\u2010causes\u2010of\u2010death(accessed: Decemeber2020)."},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2333"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.717809"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.08.001"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0804651"},{"key":"e_1_2_11_3_3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30003-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.12.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717160115"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-005-0408-9"},{"key":"e_1_2_11_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904106"},{"key":"e_1_2_11_5_4","doi-asserted-by":"publisher","DOI":"10.3390\/v13040680"},{"key":"e_1_2_11_6_1","volume-title":"Ciba Foundation Symposium 65 \u2010 Oxygen Free Radicals and Tissue Damage","author":"Klebanoff S. 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