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Existing stimuli\u2010responsive contractile materials designed for autonomous wound closure frequently lack sufficient output work density to generate the force needed to bring the wound edges into proximity or necessitate stimuli that are not compatible with the human body. Here, semi\u2010transparent, flexible, and water\u2010responsive shrinkable films, composed of poly(ethylene oxide) and \u03b1\u2010cyclodextrin, are reported. These films exhibit remarkable stability under ambient conditions and demonstrate significant contraction (\u224850%) within 6 s upon exposure to water, generating substantial contractile stress (up to 6\u00a0MPa) and output work density (\u22481028\u00a0kJ m\n                    <jats:sup>\u22123<\/jats:sup>\n                    ), which is 100 times larger than that of conventional hydrogel and 25 times larger than that of skeletal muscles. Remarkably, upon hydration, these films are capable of lifting objects 10\u00a0000 times their own weight. Leveraging this technology, water\u2010shrink tapes, which, upon contact with water, effectively constrict human skin and autonomously close bleeding wounds in animal models within 10 seconds, are developed further. This work offers a novel approach to skin wound management, showing significant potential for emergency and self\u2010care scenarios.\n                  <\/jats:p>","DOI":"10.1002\/adma.202403551","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:22:27Z","timestamp":1717586547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Rapid\u2010Response Water\u2010Shrink Films with High Output Work Density Based on Polyethylene Oxide and \u03b1\u2010Cyclodextrin for Autonomous Wound Closure"],"prefix":"10.1002","volume":"36","author":[{"given":"Junqi","family":"Yi","sequence":"first","affiliation":[{"name":"Institute for Digital Molecular Analytics and Science (IDMxS) Nanyang Technological University  59 Nanyang Drive Singapore 636921 Singapore"},{"name":"Innovative Centre for Flexible Devices (iFLEX) Max Planck\u2013NTU Joint Lab for Artificial Senses School of Materials Science 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