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The most effective therapy for SCD prevention is implantable cardioverter defibrillators (ICDs). However, ICDs contribute to adverse remodeling and disease progression and do not prevent arrhythmia. This work develops an injectable collagen\u2010PEDOT:PSS (poly(3,4\u2010ethylenedioxythiophene) polystyrene sulfonate) hydrogel that protects infarcted hearts against ventricular tachycardia (VT) and can be combined with human induced pluripotent stem cell (hiPSC)\u2010cardiomyocytes to promote partial cardiac remuscularization. PEDOT:PSS improves collagen gel formation, micromorphology, and conductivity. hiPSC\u2010cardiomyocytes in collagen\u2010PEDOT:PSS hydrogels exhibit near\u2010adult sarcomeric length, improved contractility, enhanced calcium handling, and conduction velocity. RNA\u2010sequencing data indicate enhanced maturation and improved cell\u2010matrix interactions. 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