{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:06:58Z","timestamp":1793696818679,"version":"4.5.1"},"reference-count":52,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103403"],"award-info":[{"award-number":["2022YFA1103403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504401"],"award-info":[{"award-number":["2023YFC3504401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Engineered hydrogel patches have shown promising therapeutic effects in the treatment of myocardial infarction (MI), especially anisotropic patches that mimic the characteristics of native myocardium have attracted widespread attention. However, it remains a great challenge to develop cardiac patches with long\u2010range and orderly electrical conduction based on an effective, mild, and rapid strategy. Here, a multifunctional anisotropic cardiac patch is presented based on microfluidic manipulation. The anisotropic alginate\u2010gelatin methacrylate hydrogel patches are easily and rapidly prepared through microfluidic focusing, ion\u2010photocrosslinking, and parallel packing processes. The fluid\u2010based anisotropic realization process does not involve complex machining and strong field stimulation and is compatible with the loading of macromolecular biological agents. The anisotropic hydrogel patch can mimic the anisotropy of the myocardium and guide the directional polarization of cardiomyocytes. In animal model experiments, it also exhibits significant effects in inhibiting ventricular remodeling, fibrosis, and enhancing cardiac function recovery after MI. These comprehensive features make the multifunctional hydrogel patch a promising candidate for cardiac tissue repair and future provide a new paradigm for expanding microfluidic technology to solve tissue engineering challenges.<\/jats:p>","DOI":"10.1002\/adma.202404071","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:25:41Z","timestamp":1726460741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A Multifunctional Anisotropic Patch Manufactured by Microfluidic Manipulation for the Repair of Infarcted Myocardium"],"prefix":"10.1002","volume":"36","author":[{"given":"Xiaomeng","family":"Jia","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Ai","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suet","family":"Cheung","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Hu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of TCM Basic Research on Prevention and Treatment of Major Disease Experimental Research Center China Academy of Chinese Medical Sciences  Beijing 100700 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-038X","authenticated-orcid":false,"given":"Qionglin","family":"Liang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology Department of Chemistry Laboratory of Flexible Electronics Technology Center for Synthetic and Systems Biology Tsinghua University  Beijing 100084 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31419-9"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.02.01"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b01097"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201701664"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705082"},{"key":"e_1_2_7_3_4","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00104-y"},{"key":"e_1_2_7_3_5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211915"},{"key":"e_1_2_7_3_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302335"},{"key":"e_1_2_7_3_7","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01472-w"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.160"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202201411"},{"key":"e_1_2_7_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00796-9"},{"key":"e_1_2_7_4_4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300866"},{"key":"e_1_2_7_4_5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202108489"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05168"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704235"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2020.08.029"},{"key":"e_1_2_7_5_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42008-9"},{"key":"e_1_2_7_5_5","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303429"},{"key":"e_1_2_7_5_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202101447"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00885-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37716-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201702713"},{"key":"e_1_2_7_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105777"},{"key":"e_1_2_7_7_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.1c00146"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01062"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200217"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120204"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909880"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202207590"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/la401702w"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.183"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24804-3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.029"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c03060"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204509"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113390"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101855"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903668"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3727\/46\/11\/114002"},{"key":"e_1_2_7_15_3","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.99.094502"},{"key":"e_1_2_7_15_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01084"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01591-1"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy145"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740233"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500492"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0380-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008715"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn503693h"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.06.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.136988"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202404071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202404071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202404071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:38:24Z","timestamp":1790253504000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202404071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":52,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/adma.202404071"],"URL":"https:\/\/doi.org\/10.1002\/adma.202404071","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2024-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2404071"}}